Friday, January 24, 2014

what is the Erythromycin ?


Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often prescribed for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and legionellosis. It was first marketed by Eli Lilly and Company, and it is today commonly known as EES . It is also occasionally used as a prokinetic agent.Erythromycin displays bacteriostatic activity or inhibits growth of bacteria, especially at higher concentrations, but the mechanism is not fully understood. By binding to the 50s subunit of the bacterial 70s rRNA complex, protein synthesis and subsequent structure and function processes critical for life or replication are inhibited. Erythromycin interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the rRNA complex to the P site of the rRNA complex. Without this translocation, the A site remains occupied and, thus, the addition of an incoming tRNA and its attached amino acid to the nascent polypeptide chain is inhibited. This interferes with the production of functionally useful proteins, which is the basis of this antimicrobial action.Grade:USP grade

CAS: 114-07-8
Molecular Formula: C37H67NO13
Molecular Weight: 733.94 g/mol
Specification:5g/5g each/10g/50g/50g original binding

The use of Carmustine or BCNU


Carmustine or BCNU  is a mustard gas-related β-chloro-nitrosourea compound used as an alkylating agent in chemotherapy. As a dialkylating agent, BCNU is able to form interstrand crosslinks in DNA, which prevents DNA replication and DNA transcription.It is used in the treatment of several types of brain cancer , multiple myeloma and lymphoma . BCNU is sometimes used in conjunction with alkyl guanine transferase (AGT) inhibitors, such as O6-benzylguanine. The AGT-inhibitors increase the efficacy of BCNU by inhibiting the Direct Reversal pathway of DNA repair, which will prevent formation of the interstrand crosslink between the N1 of guanine and the N3 of cytosine.
Carmustine or BCNU is also used as part of chemotherapeutic protocol to prepare for hematological stem cell transplantation, to reduce the white blood cells in the recipient. This use under this protocol, usually with Fludarabine and Melphalan, was coined by oncologist at MD Anderson Cancer Center.
CAS:     154-93-8
Molecular Formula:     C5H9Cl2N3O2
Formula Weight:     214.05

Thursday, January 23, 2014

what is Flumazenil ?


Flumazenil  is a benzodiazepine antagonist.It has been used as an antidote in the treatment of benzodiazepine overdoses.
Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures.It has been used as an antidote in the treatment of benzodiazepine overdoses It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.
It has been found to be effective in overdoses of non-benzodiazepine sleep enhancers, namely zolpidem, zaleplon and zopiclone.
Flumazenil  was recently found effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia. It has also been used in hepatic encephalopathy, though results have been mixed.

Information about Terbinafine hydrochloride


Terbinafine is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. As a generic it is sold under the name Zabel in Australia. It is now also available as a generic in the United States, Belgium, Switzerland, Russia, and most or all of the former Soviet Union. Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water.Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis.
CAS:91161-71-6
Molecular Formula:C21H26ClN
Molecular Weight:327.89g/mol

Wednesday, January 22, 2014

what is the Methandrostenolone ?


Methandrostenolone  is an orally-effective anabolic steroid originally developed in Germany and released in the US in the early 1960s by Ciba Specialty Chemicals. Methandrostenolone is a controlled substance in the United States and Western Europe and remains popular among bodybuilders. An injectable form is sold online from United States based companies. Methandrostenolone is readily available without a prescription in countries such as Mexico (under the trade name Reforvit-b), and is also being manufactured in Asia and many East European countries.
In the early 1960s, doctors commonly prescribed 3 tablets per day for women as a tonic. This use was quickly discontinued upon discovery of the heavily masculinising effects of methandrostenolone.Despite the lack of any known therapeutic applications, the drug remained legal until the early 2001[citation needed]. The United States Congress added certain kinds of steroids which may or may not include methandrostenolone to the Controlled Substances Act as an amendment known as the Anabolic Steroid Control Act of 1990[citation needed]. This act placed steroids in the same category as some amphetamines as a "Schedule III" drug and possession of these drugs results in a felony. Contrary to popular belief, steroids were banned by Congress without the support of the FDA, the American Medical Association, the DEA or the National Institute on Drug Abuse. It's used by bodybuilders, and methandrostenolone continues to be used illegally to this day, typically being combined (stacked) with injectable compounds, such as testosterone propionate, enanthate, cypionate as well as other injectable drugs like trenbolone acetate.
Several successful athletes and professional bodybuilders have come forward and admitted long-term Methandrostenolone use before the drug was banned, including Arnold Schwarzenegger , Ronnie Coleman and Phil Heath .

about Ketoprofen


Ketoprofen is an oral drug that belongs to a class of drugs called nonsteroidal antiinflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), naproxen (Aleve) and many others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Ketoprofen reduces prostaglandins by blocking the enzyme that makes them (cyclooxygenase). As a consequence, inflammation, pain and fever are reduced.
Ketoprofen is a common NSAID, antipyretic, and analgesic used in horses and other equines. It is also used as a mild painkiller in smaller animals, generally following surgical procedures. It is most commonly used for musculoskeletal pain, joint problems, and soft tissue injury, as well as laminitis. It is also used to control fevers and prevent endotoxemia. However, it may mask the symptoms of the underlying problem, and therefore make diagnosis more difficult for a veterinarian.
Ketoprofen should not be used in combination with other NSAIDs or corticosteroids, as this increases the risk of gastrointestinal (GI) ulceration. It should also be used with caution with other anticoagulants. It is commonly used with omeprazole, sucralfate, and cimetidine to help protect the GI tract.
CAS:22071-15-4
Specification: BP98/EP5/USP30
Molecular Formula:C16H14O3
Molecular Weight:254.28g/mol

Tuesday, January 21, 2014

what is the Nano-alumina wear-resistance powder ?


Nano-alumina wear-resistance powder is specially used for a variety of paint, primer, coating ,it can enhance wear resistance, increase hardness, and have good dispersion and good transparency,
Nano-alumina wear-resistance powder can play a reinforcing role in enhancing the coating's hardness and wear resistance, hardness increased with the addition increased.
Item noJR-NL16JR-NL17
Appearance  White powderWhite powder
Content of alumina﹪ ≥99.599.5
Surface Propertieshydrophobichydrophilic
BET(m2/g)8-158-15
Particle size,D502-3um1-2um
1. Nano-alumina wear-resistance powder  does not affect the adhesion and transparency of coating when it is added in coating.
2.The product can reduce the volume of shrinkage during curing ,and can improve the adhesion between the coating and the substrate.
3. The thermal stability of coating will increase with increasing the dosage