Information about Atorvastatin calcium

Atorvastatin calcium is a synthetic lipid-lowering agent.Atorvastatin is an inhibitor of 3 hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol.The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.
Atorvastatin is absolutely contraindicated in pregnancy; it is likely to cause harm to fetal development because of the importance of cholesterol and various products in the cholesterol biosynthesis pathway for fetal development, including steroid synthesis and cell membrane production. Nursing mothers are not recommended to take atorvastatin due to the possibility of adverse reactions in nursing infants, since experiments with rats indicate atorvastatin is likely to be secreted into human breast milk.
Molecular Formula:C66H68CaF2N4O10
Molecular Weight:1155.36
CAS Number:134523-03-8
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