Information about Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug.It is used for relief of symptoms of arthritis, primary dysmenorrhea, fever, and as an analgesic, especially where there is an inflammatory component. Ibuprofen is known to have an antiplatelet effect, though it is relatively mild and short-lived when compared with that of aspirin or other better-known antiplatelet drugs.
Ibuprofen is used primarily for fever, pain, dysmenorrhea and inflammatory diseases such as osteoarthritis and rheumatoid arthritis.It is also used for pericarditis and patent ductus arteriosus. Ibuprofen has a dose-dependent duration of action of around four to eight hours, which is longer than suggested by its short half-life. Onset of analgesia (time to effect) is 24.5 minutes using liquigel format orally. The recommended dose varies with body mass and indication. A dose of 400 mg per dose and 1200 mg per day is considered the maximum amount for over-the-counter use in the United States.

In Europe, Australia, and New Zealand, ibuprofen lysine (the lysine salt of ibuprofen, sometimes called "ibuprofen lysinate" even though the lysine is in cationic form) is licensed for treatment of the same conditions as ibuprofen. The lysine salt increases water solubility, allowing intravenous use, and is indicated for closure of a patent ductus arteriosus in premature infants weighing between 500 and 1,500 grams (1 and 3 lb), who are no more than 32 weeks gestational age when usual medical management  is ineffective.
With regard to this indication, ibuprofen lysine is an effective alternative to intravenous indomethacin, and may be advantageous in terms of kidney function.[15] Ibuprofen lysine has been shown to have a more rapid onset of action compared to acid ibuprofen.