what is Flumazenil ?

Flumazenil  is a benzodiazepine antagonist.It has been used as an antidote in the treatment of benzodiazepine overdoses.
Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures.It has been used as an antidote in the treatment of benzodiazepine overdoses It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.
It has been found to be effective in overdoses of non-benzodiazepine sleep enhancers, namely zolpidem, zaleplon and zopiclone.
Flumazenil  was recently found effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia. It has also been used in hepatic encephalopathy, though results have been mixed.