The characteristics of Methyl 2-amino-3-methylbenzoate

Name:  Methyl 2-amino-3-methylbenzoate 
Synonym: Methyl 3-methyl-2-aminobenzoate; 2-Amino-3-methylbenzoic acerbic methyl ester
In the mol­ecule of the appellation compound, C9H11NO2, the methyl C and amino N atoms affirmed to the benzene ring lie in the ring plane. Intra­molecular C—HO hydrogen bonding after-effects in the accumulation of a five-membered collapsed ring, which is aggressive at a dihedral bend of 2.73 (3)° with account to the benzene ring, so they are about coplanar. In the clear structure, inter­molecular N—HO hydrogen bonds hotlink the mol­ecules into chains continued forth the c arbor and ample forth the b axis.Methyl 3-methyl-4-aminobenzoate is important as an intermedicine to adapt telmisartan, an angiotensin II receptor blocker, on the development of blubber and accompanying metabolic disorders in diet-induced adipose mice (Ries et al., 1993). Telmisartan can be acclimated as a ameliorative apparatus for metabolic syndrome, including belly blubber (Engeli et al., 2000; Kintscher et al., 2004; Goossens et al., 2003; Kurtz et al., 2004). As allotment of our studies in this area, we address herein the amalgam and clear anatomy of the appellation compound, (I).In the atom of (I), (Fig. 1), the ligand band lengths (Allen et al., 1987) and angles are aural accustomed ranges. The atoms N and C9 lie in the benzene ring plane. The intramolecular C—H···O hydrogen band (Table 1) after-effects in the accumulation of a five-membered collapsed ring A (O1/C2/C3/C4/H4A), in which it is aggressive with account to the six-membered collapsed ring B (C3—C8) at a dihedral bend of A/B = 2.73 (3)°. So, they are aswell about coplanar.
In the clear structure, intermolecular N—H···O hydrogen bonds (Table 1) hotlink the molecules into chains continued forth the c arbor and ample forth the b arbor (Fig. 2), in which they may be able in the stabilization of the structure.
Properties
Melting point: 115-117 ºC
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