The presentation of (+)-DIP Chloride

(+)-DIP Chloride  is a trademark of Sigma-Aldrich .A convenient and economical in situ preparation of DIP-Chloridetm from NaBH4, BCl3 and α-pinene is described. Its application in the asymmetric reduction of representative aralkyl ketones is presented.Both (+)- and (-)-DIP-chloride are used for asymmetric reduction of prochiral ketones1,2 and for the preparation of β-amino alcohols.2,3
Excellent reagent for asymmetric reductions.Reagent empolyed in an enantioselective reduction of (chloroacetyl) benzofurans to chlorohydrins which serve as intermediates for the corresponding epoxides and aminoalcohols. Both (+)- and (-)-DIP-chloride are used for asymmetric reduction of prochiral ketones and for preparing β-amino alcohols.
For a short paper on the preparation of DIP halides and their use in stereoselective reductions see ACS Symp. Ser. 641, 84-97 (1996).
CAS NO.: 112246-73-8
Molecular Formula: C20H34BCl
Molecular Weight: 320.75
Description:
Density:  0.9g/ml
Usage: make medicine
Both (+)-DIP Chloride  and (-)-DIP-chloride are used for asymmetric reduction of prochiral ketones1,2 and for the preparation of β-amino alcohols.2,3
Reagent used for an enantioselective reduction of (chloroacetyl) benzofurans to chlorohydrins which serve as intermediates for the corresponding epoxides and aminoalcohols. For a short paper on the preparation of DIP halides and their use in stereoselective reductions see Chem. Commun. 1053 (1994).
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