The information of 2-Amino-1-cyclopentene-1-carbonitrile

hydroxylamine hydrochloride were added to a band-aid of 54.07 g (0.5 mol) of 2-amino-1-cyclopentene-1-carbonitrile in 250 ml of ethanol, and the admixture was acrimonious at the abscess for one hour. The accelerate formed was filtered off, and the clarify was concentrated and again taken up in a admixture of 60 ml of isopropanol and 240 ml of water. The admixture was acrimonious at 40° C., and 0.05 mol of 50 percent backbone aqueous sodium hydroxide band-aid was added dropwise at this temperature. The admixture was again afflicted at 60° C. for addition bisected an hour and again cooled to 10° C., and the solid formed was filtered off. Washing with baptize and dehydration gave 51.4 g (82% of theory) of the appellation admixture as a white solid of m.p.=135° C. The compounds of the accepted blueprint (I) in which R1 and R2 are as authentic aloft [0048] except for compounds (I) in which R1 and R2 are identical and represent =COR3-- can be able by reacting 2-amino-1-cyclopentene-1-carbonitrile of the blueprint with hydroxylamines of the accepted blueprint (II) or salts thereof, in which R1 and R2 are as authentic above, but R1 and R2 do not accompanying represent --COR3, if adapted in the attendance of diluents and if adapted in the attendance of a catalytic or stoichiometric bulk of base. The alertness of 2-amino-1-cyclopentene-1-carbonitrile has already been appear in the abstract .O-tert-butylhydroxylamine hydrochloride was added to a band-aid of 0.81 g (0.008 mol) of 2-amino-1-cyclopentene-1-carbonitrile in 10 ml of ethanol, and the admixture was acrimonious at the abscess for two hours. After cooling, the solid formed was filtered off and the clarify was concentrated. Dehydration of the balance beneath bargain burden gave 1.05 g (74% of theory) of the appellation admixture as a achromatic oil of nD24=1.4590.
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