About Desmopressin

Desmopressin (trade names: DDAVP, DesmoMelt, Stimate, Minirin) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as an oral or sublingual tablet. Physicians prescribe desmopressin most frequently for treatment of diabetes insipidus, bedwetting, or nocturia.Desmopressin is a modified form of the normal human hormone arginine vasopressin, a peptide containing nine amino acids.
Compared to vasopressin, desmopressin's first amino acid has been deaminated, and the arginine at the eighth position is in the dextro rather than the levo form .Doctors prescribe desmopressin frequently for treatment. It is usually in the form of desmopressin acetate, DDAVP. Patients taking DDAVP are 4.5 times more likely to sleep without disruption than with placebo. Examples of these situations are overnight camp and sleepovers.
US drug regulators banned treating bedwetting with desmopressin nasal sprays after two patients died and 59 other patients suffered seizures. The patients were using desmopressin when they developed hyponatremia, an imbalance of the body's sodium levels.
FDA regulators said that desmopressin tablets could still be considered safe for nocturnal enuresis treatment, as long as the patient was otherwise healthy. Patients must stop taking desmopressin if they become sick and have severe vomiting and diarrhea, fever, the flu, or severe cold. They should also be very cautious during hot weather or following strenuous exercise that may make them thirsty.
A healthy body needs to maintain a balance of water and salt . If sodium levels become too low (hyponatremia) – either as a result of increased water take-up or reduced salt levels – a person may have seizures and, in extreme cases, may die.
CAS NO:16789-98-3
Molecular formula:C₄₆H₆₄N₁₄O₁₂S₂
Molecular weight: 1069.24
Appearance:White powder
Purity(by HPLC):  ≥98.00%～99.90%
Amino Acid Composition: ±10% of theoretical
Water Content(Karl Fischer): ≤4.80%
Acetate Content(HPIC):≤6.80%