Desloratadine

Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex, Aerius and Delot . It is an active metabolite of loratadine, which is also on the market.
Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It is an antagonist at histamine H1 receptors, and an antagonist at all subtypes of the muscarinic acetylcholine receptor. It has a long-lasting effect and in moderate and low doses, does not cause drowsiness because it does not readily enter the central nervous system. Unlike other antihistamines, desloratadine is also effective in relieving nasal congestion, particularly in patients with allergic rhinitis. Desloratadine is available as tablets (including orally disintegrating and extended release) and as syrup. In Colombia (South America) it is marketed under Dexio from Laboratorios Bussié, as tablets and as syrup to children. In Nepal and India it is widely available under the trade name Daziti and Dazit.