Trandolapril is almost white or pale yellow, slightly hygroscopic powder.The melting point is 122-123°C.It is freely soluble in glacial acetic acid. Its loss on drying is not more than 0.5% and the assay is not more than 98.0%.Its heavy metal is not more than 10ppm and residue on lgnition is not more than 0.15%.It is used for an antihypertensive.It can also be used for an angiotensin converting enzyme (ACE) inhibitor. Trandolapril is a prodrug that is deesterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of about 10. Trandolaprilat has about 8 times the activity of its parent drug. Approximately 1/3 of Trandolapril and its metabolites are excreted in the urine, and about 2/3 of trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%.
CAS:87679-37-6
Molecular Formula:C24H34N2O5
Molecular Weight: 430.54g/mol
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